Rolling stock manufacturers face the challenge of manufacturing lightweight high-speed trains without deteriorating comfort.One of the difficulties is to mantain or increase structural stiffness and damping as the car bodies become lighter.Leaving aside active solutions, which are expensive and generally complex to implement, increasing structural
Lea Tami Suzuki Zuchelo,1,2 Italla Maria Pinheiro Bezerra,1,3 Adna Thaysa Marcial Da Silva,1,4 Jéssica Menezes Gomes,1,4 José Maria Soares Júnior,4 Edmund Chada Baracat,4 Luiz Carlos de Abreu,1,3 Isabel Cristina Esposito Sorpreso1,4 1Study Design and Scientific Writing Laboratory at ABC Medical School, Santo André, Brazi
ABSTRACT Objective To evaluate the cost-effectiveness of the addition of chemotherapy or abiraterone to androgen deprivation.Methods We developed an analytical model to determine the cost-effectiveness of the addition of docetaxel or abiraterone versus androgen deprivation therapy alone.Direct and indirect costs were included in the model.The effec